Department of Biostatistics and Bioinformatics, Duke University, Durham, USA
Abstract:While Large Language Models (LLMs) achieve impressive performance on multi-step reasoning tasks, their reliability is persistently hindered by critical limitations such as unconstrained hallucinations and poor numerical computation. Fundamentally, these issues arise because standard models treat reasoning as a transient, one-off generation process rather than retaining and refining successful procedural logic. To address these challenges, we propose eMoT (evolving Memory-of-Thought), a unified framework that stabilizes multi-step reasoning by treating reasoning trajectories as dynamic, evolving memories rather than static templates. The framework primarily consists of three interconnected modules: (i) a memory corrosion mechanism that reinforces high-utility reasoning structures while gradually decaying less frequent ones; (ii) a symbolic anchoring engine that utilizes Python for deterministic computation, much like a human uses a calculator; and (iii) a consistency-driven refinement process that aligns neural inference with symbolic outcomes, reducing the accumulation of logical discrepancies. Across multiple reasoning benchmarks, eMoT improves accuracy and solution consistency over standard Chain-of-Thought and structured reasoning baselines.On the traditional task Game of 24, eMoT achieves 100% accuracy, surpassing the baseline by up to 17.6%. Evaluations on mathematical task GSM8K, ASDiv, SVAMP, and MGSM further show consistent gains in multi-step mathematical reasoning. In our evaluation, we achieve superior performance despite utilizing a lightweight backbone model with constrained baseline capabilities. Compared to alternative methods that rely on massively scaled models, our results demonstrate that the performance gains are fundamentally driven by the eMoT framework's reasoning control rather than sheer model size.
Abstract:The demand for powerful instruction following and reasoning capability of large language models (LLMs) has promoted rapid development of retrieval-augmented generation (RAG). The RAG system assists LLM generation by retrieving chunks of query-fit supplementary knowledge from an external database. Conventional RAG systems, however, suffer from information insufficiency due to two factors, which are intent-agnostic retrieval and information fragmentation. Our work proposes a RAG framework, termed InSemRAG, that addresses these challenges via an iterative retrieve-and-check mechanism with two supporting modules, an intention-aware retriever (IAR) and semantics-preserving chunking (SPC). IAR implements a dynamic hybrid retrieval method that adaptively weights the retrieval channels based on the query intent, while SPC performs detection and reparation to the damaged evidence chunks to preserve the semantic integrity. To alleviate the computational latency brought by our iterative mechanism, we leverage small language models (SLMs). Extensive experiments across several benchmark datasets consistently demonstrate the competitiveness of our method against recent state-of-the-art RAG mechanisms. Particularly, our method achieves significant gains on multi-hop and evidence-sensitive tasks, with a 2.65-point improvement in F1 on HotPotQA and a 1.5-point increase in accuracy on FEVER. Our method also achieves competitive performance to Multi-Hop RAG with 4.32$\times$ lower latency with the utilization of SLM.
Abstract:Understanding the human brain requires access to its microscopic tissue architecture. Diffusion magnetic resonance imaging (MRI) provides the only noninvasive window into whole-brain microstructure in vivo, yet reliable quantitative mapping remains confined to specialized research settings requiring dense sampling and optimized acquisition protocols. To address this gap, we present a physics-informed generative microstructure network (PIGMENT) that learns a universal generative prior of human brain microstructure and adapts it zero-shot to each participant's measured data to recover subject-specific maps. Trained on 11375 scans spanning multiple sites, vendors, and field strengths, PIGMENT enabled reliable quantitative mapping for tensor, kurtosis, and NODDI models across external datasets from five independent centers. It remains effective where conventional fitting becomes unreliable, recovering meaningful maps from extremely sparse acquisitions while supporting downstream tractography and structural connectivity mapping. PIGMENT estimates demonstrated strong biological validity, preserving submillimeter cortical microarchitectural patterns and early-childhood white matter developmental trajectories from 10-fold accelerated scans. Furthermore, PIGMENT enables reliable quantitative tensor mapping on cost-efficient low-field systems and the extraction of tumor-related biomarkers using ultra-fast clinical protocols. Together, these results establish PIGMENT as a physics-informed foundation model that extends quantitative diffusion MRI into regimes traditionally too sparse, heterogeneous, or clinically constrained for reliable analysis.
Abstract:Pilot readback of Air Traffic Control (ATC) voice instructions is a primary safeguard against miscommunication in air transportation. However, readback anomalies remain implicated in approximately 80% of aviation incidents. This vulnerability is further exacerbated by rising traffic volume and elevated cognitive workload, thereby motivating automated readback monitoring by machine. Traditional rule-based and machine learning approaches struggle to generalize across the highly variable and evolving phraseology of air traffic controller-pilot communications. While Large Language Models (LLMs) have opened a new avenue through their strong reasoning and generalization capabilities, existing approaches still face deployment and computational barriers in practice. In this work, we propose Semantic reasoning for Communication via Open-set Plug-in with Examples (SCOPE), a novel lightweight-training LLM framework that advances both the efficiency and accuracy of machine-based ATC readback monitoring. The core idea is to couple a plug-in open-set classifier with a carefully designed in-context learning mechanism on top of a frozen LLM. Extensive experiments on the semi-synthetic communication dataset show that SCOPE attains superior accuracy while delivering the low-latency response required for operational environments. Under a few-shot setting, SCOPE achieves 91.05% accuracy in open-set detection and corrects 96.63% of anomalous readbacks, thereby outperforming the strongest available baselines while providing explanations for its decisions. These findings demonstrate the potential of our framework as a practical pathway toward interpretable and controllable ATC readback monitoring.
Abstract:Neural operators learn mappings from function-dependent inputs to solutions, providing an effective framework for solving partial differential equations (PDEs). For time-dependent PDEs, existing methods typically perform long-horizon prediction through autoregressive rollout directly in high-dimensional physical field spaces, where each predicted state is recursively fed back as the input for the next step. Although effective for short-term prediction, this autoregressive rollout and the lack of continuous-time modeling lead to progressive error accumulation over long-horizon rollouts. In this work, we propose Autoregression-Free Neural Operators (AFNO), which map the time evolution of PDEs into a latent space and model continuous-time vector fields within it. AFNO uses flow matching to learn the latent vector field, thereby enabling continuous evolution over extended horizons, avoiding autoregressive rollout and capturing dynamics under varying parameter configurations through explicit conditioning on physical parameters. Theoretical analysis and extensive experiments on six PDEs demonstrate that AFNO improves long-horizon prediction stability and consistently reduces rollout errors compared with the baselines.
Abstract:Given a strategically complex board game, human players can quickly learn to devise strategies after playing a few rounds. Autonomous agents require similar capabilities in realistic interactive environments, yet existing agent benchmarks often fail to fully capture such strategic and evolving decision-making scenarios. We present PTCG-Bench, a benchmark built on the Pok'{e}mon Trading Card Game (PTCG) that evaluates LLM agents at two complementary levels: (1) their decision-making performance within a single complex environment, and (2) their ability to self-evolving through accumulated experience. We further include a modular harness ablation to better interpret agent performance without conflating it with model capability. Our experiments show that, although LLM agents can achieve non-trivial gameplay performance, sustained and stable self-evolution remains challenging, and performance is sensitive to harness design. We hope that PTCG-Bench will facilitate future research on harness-aware and self-evolving agents in realistic interactive environments.
Abstract:Out-of-distribution (OOD) detection is essential for deploying machine learning models in open-world and safety-critical scenarios, where test inputs may deviate from the training distribution and overconfident predictions on unknown samples can lead to unreliable decisions. Outlier Exposure (OE) has emerged as a promising OOD detection paradigm by introducing auxiliary outliers during training to enlarge the margin between in-distribution (ID) and OOD samples. Existing OE-based methods typically enlarge this margin by employing uniform labels to maximize the entropy of OOD samples over ID categories. However, we theoretically show that uniform labels inevitably disregard the relations between OOD samples and ID categories, termed the over-softening effect, leading to a suboptimal margin bound. Our theoretical analysis further reveals that explicitly exploiting such relations can instead yield improved OOD detection performance. Motivated by this insight, we propose \underline{A}daptive Confidence \underline{OE} (AOE), a simple yet effective method that leverages temperature scaling to recalibrate outlier labels. Specifically, AOE generates adaptive soft targets from temperature-scaled model predictions for OOD samples, where the learnable temperature smooths the prediction distribution without fully erasing class-wise relational information. By supervising OOD samples with these adaptive soft targets, AOE preserves the semantic proximity between OOD samples and ID categories while encouraging the softened targets to approach a high-entropy distribution, thereby suppressing overconfident OOD predictions and enlarging the separation margin. Extensive experiments across diverse benchmarks demonstrate the effectiveness of AOE.
Abstract:With rapid advances in audio-visual generative models, reliable forgery detection becomes increasingly critical. Existing methods for audio-visual deepfake detection typically rely on cross-modal inconsistencies. In singing, rhythmic vocalization weakens this coupling and introduces a nontrivial domain shift, substantially degrading detection performance. We construct the Singing Head DeepFake (SHDF) dataset using rhythm-aware generative models to fill the gap in singing benchmarks. To cope with cross-scenario domain shifts, we propose a Text-guided Audio-Visual Forgery Detection (T-AVFD) framework that generalizes across both talking and singing scenarios. T-AVFD comprises a facial authenticity pattern learner and a multi-modal differential weight learning module. The pattern learner aligns facial features with multi-granularity textual descriptions to learn generalizable authenticity patterns. The weight learning module preserves intrinsic audio-visual consistency and adaptively integrates it with authenticity patterns via differential weighting. Extensive experiments on multiple talking head deepfake datasets and SHDF show consistent improvements over existing baselines and strong robustness under diverse perturbations.
Abstract:Camouflaged object detection (COD) aims to localize targets that exhibit minimal perceptual differences from backgrounds through physical attributes. Existing methods, constrained by the static train-then-freeze paradigm, suffer from domain rigidity and annotation dependency, limiting their adaptability to scene variations and unseen camouflage patterns. To overcome these, we propose the hierarchical consistency learning (HCL) framework, which integrates test-time adaptation for dynamic representation recalibration. Specifically, we design the hierarchical representation reconstruction (HRR) to alleviate feature entanglement by synergizing spatial reconstruction with dual-stream frequency-domain decomposition, enhancing robustness against appearance homogenization. The pixel and spectrum inference provide structural and contextual priors. We further introduce task affinity guidance (TAG) to propagate knowledge across branches via channel-wise affinity, aligning local discriminative cues and mitigating semantic drift. To ensure semantic invariance, we formulate the prototype consistency calibration (PCC), which aggregates region features into compact prototypes and establishes prototype-feature similarity. This imposes implicit and hierarchical constraints that bridge task and representation gaps. Extensive experiments across four camouflaged and four underwater object benchmarks, under three degradation settings, demonstrate that our method consistently outperforms state-of-the-art approaches, highlighting its robustness and generalization under distribution shifts.
Abstract:Recently, Reinforcement Learning with Verifiable Rewards (RLVR) and Test-Time Scaling (TTS) have advanced LLM code generation through executable verification. Yet Ground-Truth Unit Tests (GT UTs) remain a bottleneck: SOTA RLVR methods require them for costly training, while existing TTS methods lose competitiveness without them. This motivates GT-free TTS, where existing methods directly use self-generated UTs to refine and select code candidates. Yet such UTs are often noisy or spuriously coupled with wrong code, and UT quality in turn cannot be validated without reliable code. The key challenge is therefore to jointly improve both. To this end, we present CoSPlay, a GT-free, training-free framework that jointly improves codes and UTs through cooperative self-play. It first explores diverse solution ideas and identifies their potential failure modes to produce discriminative UT ideas. It then uses bidirectional pass-count signals from the Code-UT execution matrix to iteratively prune or fix weak codes and refresh or replace unreliable UTs, letting the two pools co-evolve. Finally, when multiple codes remain tied at the highest pass count, it picks the final code from the largest output-consensus cluster, since correct codes agree on the same inputs while wrong codes diverge. Experiments on four challenging benchmarks show that CoSPlay on Qwen2.5-7B-Instruct improves average BoN from 22.1% to 33.2% and UT accuracy from 14.6% to 78.3%, matching or surpassing the RLVR model CURE-7B. When applied to CURE-7B, it further improves BoN by 5.7%. CoSPlay also generalizes across diverse backbones and outperforms GT-free TTS baselines under comparable token budgets, with continued gains as the budget scales up. These results suggest a scalable inference strategy for competitive code generation without any GT data.